At last, using public available data from four different studies we determined that the expression of Dnmt3a is significantly reduced in squamous cell carcinomas and actinic keratosis, the premalignant stage of squamous tumors, compared to human healthy epidermis (Figure 7—figure supplement 1 and Figure 7—figure supplement 1—Source data 1). This evidence concerns the gene DNMT3A and squamous cell carcinoma.