Indeed, a detailed histological analysis of the tumors collected from Dnmt3a-cKO and wild-type animals indicated that Dnmt3a-cKO mice developed the same percentage of benign tumors, such as keratoacanthomas and papillomas, as well as of malignant invasive papillomas and squamous cell carcinomas (SCCs) (Figure 1E). Here, DNMT3A is linked to papilloma.