An increased expression of transcriptional factors for osteoblast differentiation, such as RUNX2 and Osx, has been found in bone samples obtained by osteoarthritis patients than compared to osteoporotic patients, suggesting a more intense osteoblastogenesis in osteoarthritis than in osteoporosis (Dragojevič, Logar, Komadina, & Marc, 2011). Here, SP7 is linked to osteoarthritis.