In particular, an altered ratio of α1 and α2 chains of type I collagen, with an increased production of the α1 chain, plays a key role in the abnormal mineralization of osteoarthritis bone and may be responsible for the increased levels of transforming growth factor‐β (TGF‐β) in osteoarthritis osteoblasts (Couchourel et al., 2009; Zhen et al., 2013), which is involved in osteophytes production and promotes mineralization via the inhibition of bone morphogenic protein‐2 (BMP‐2) (Neve et al., 2011). This evidence concerns the gene TGFB1 and osteoarthritis.