Additional studies have shown that SOX1 alters SOX2 expression in human laryngeal squamous cell carcinoma60, regulates p27KIP levels in hepatocellular carcinoma23, and modulates CYCLIN D1 expression in hepatocellular and nasopharyngeal carcinoma as well as in breast cancer23, 25, 54. Here, SOX2 is linked to nasopharyngeal carcinoma.