The substitutions P35L, D37N, E40K and T42A (Fig. 3B) have been selected considering the conservation of the CODD motif, their position on the interaction surface as well as their pathological relevance in cancer43, i.e. hematological malignancies compatible with the deregulation of the pVHL/HIF-1α axis. This evidence concerns the gene HIF1A and hematologic disorder.