CD80 and primary biliary cholangitis: Recently, we performed a replication study of the 14 most significant single nucleotide polymorphisms (SNPs) identified in either or both of the European and Japanese cohorts, using 1,070 Han Chinese PBC cases and 1,198 healthy controls, and confirmed strong association of the TNFSF15, CD80 and 17q12 loci with the disease in Chinese patients, with P-value reaching GWA significance (P<5 × 10−8) at TNFSF15 and CD80 loci9.