IGF1R and central nervous system cancer: Epidermal growth factor receptor (EGFR) promotes the malignant potential of glioma cells by interacting with the functional subunit of the cysteine/glutamate transporter xc-system (xCT) at the cell surface58; the expression of insulin-like growth factor 1 receptor (IGF1R) was found to be associated with the proliferation, migration, invasion, and tumorigenesis of glioma cells59.