Serum ATX increased significantly according to liver fibrosis progression (r = 0.72, P < 0.001 overall, r = 0.77, P < 0.001 in men, and r = 0.73, and P < 0.001 in women) and activity (r = 0.46, P < 0.001 overall, r = 0.69, P < 0.001 in men, and r = 0.66, P < 0.001 in women). Here, ENPP2 is linked to Hepatic fibrosis.