MAPT and Mental deterioration: However, other pathologies may contribute to the cognitive symptoms of DLB and should be investigated further; one study has previously observed that cognitive decline in LBD may be a consequence of alpha‐synuclein, amyloid‐beta and phosphorylated tau pathology (Howlett et al.,2015), and additionally, one study of the medial temporal lobe showed that alpha‐synuclein pathology, rather than AD pathology, had a role in the atrophy of the amygdala (Burton et al.,2012).