In recent years, in vitro studies have demonstrated that SMAC mimetics, in combination with anticancer drugs and TRAIL (TNF-related apoptosis-inducing ligand) can effectively enhance apoptosis and cell death in numerous cancer cell types, including T98G glioblastoma cells [146], HeLa cells [147] and lung adenocarcinomas [148]. This evidence concerns the gene TNFSF10 and cancer.