Alterations in the pattern of seasonal cytokine variation have also been observed in MS patients: seasonal variation is seen in healthy controls in IL-4, IL-10, TNF-α, and IFN-γ, but in untreated MS patients, only seasonal variation in IL-10 was preserved, while in treated MS patients, the seasonal variation was lost for all four cytokines [27]. This evidence concerns the gene IL4 and myeloid sarcoma.