The formation of tumor microenvironment could lead to the infiltration of immunosuppressive cells such as myeloid derived suppressor cell, regulatory T cell and tumor associated macrophage, upregulation of a series of proinflammatory factors, and accumulation of a large number of inflammatory cytokines such as IL-6, IL-11, TGF-β, and MMP. This evidence concerns the gene IL6 and neoplasm.