In current study, the daily consumption of salacca vinegar from diverse salacca fruits by STZ-induced diabetic rats indicated their capability as a therapeutic agent for hyperglycemia and hyperlipidemia as demonstrated by blood glucose level, islet β cell performance, SOD, and MDA levels, as well as HDL, LDL, TG, and total cholesterol levels. This evidence concerns the gene SOD1 and Hyperglycemia.