As a fully humanized monoclonal antibody (mAb) that binds vascular endothelial growth factor-A (VEGF-A) and prevents interaction with VEGFR-1 and VEGFR-2 (the primary receptors involved in endothelial cell proliferation and migration), bevacizumab was thought of as a “silver bullet” capable of targeting multiple types of cancer since tumor proliferation and spread depend on neo-vasculature (2–4). The gene discussed is VEGFA; the disease is cancer.