Moreover, it seems that lymphocyte influx across the vascular endothelium toward the tumor is affected by VEGF, which leads to a defect in intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 clustering at the endothelial cell surface through nitric oxide production and subsequently leads to defective lymphocyte adhesion and migration toward the tumor environment (63). Here, ICAM1 is linked to neoplasm.