ALK and non-small cell lung carcinoma: Furthermore, a retrospective pooled analysis of single-arm phase 1 and 2 studies of crizotinib in advanced ALK-positive NSCLC, PROFILE 1007 (13) and 1005 (12), demonstrated a median overall survival (OS) of 29.6 months for 120 patients who were allowed to continue crizotinib beyond progressive disease (PD) because they continued to derive clinical benefit from it.