EGFR and non-small cell lung carcinoma: In a pooled analysis including 464 patients from 16 trials to study the efficacy of EGFR TKIs in NSCLC patients with activating EGFR mutations with BM showed that EGFR TKIs produce significant beneficial effects, with a pooled objective ICRR of 51.8%, IDCR of 75.7%, median PFS of 7.4 months, and OS of 11.9 months (23) (Table 1).