Several lines of evidence support the role for gingipains in chemerin inactivation: (1) mRNA encoding all three gingipains (RgpA, RgpB, and Kgp) was present in higher levels and in a larger number of patients with periodontitis compared with individuals with gingivitis (Table 2); and (2) P. gingivalis supernatants inactivated chemS157 in the gingipain-dependent manner (Figure 6B). Here, RARRES2 is linked to periodontitis.