INS and type 2 diabetes mellitus: Epidemiological evidence has also shown that patients with T2DM have increased risk for breast, colon, prostate, kidney, and pancreatic cancers (Belfiore, 2007; Huang et al., 2011; Kalla Singh et al., 2011), an effect that has been associated with high insulin plasma levels (Giovannucci et al., 2010).