On the other hand, Tau pathology in AD follows a highly predictable progression, predates Aβ accumulation in anatomical studies, and shows a parsimonious relationship with cognitive symptom development (Braak and Del Tredici, 2011; Walsh et al., 2017) being the basis for the most accepted staging system of AD pathology (Braak and Braak, 1991). This evidence concerns the gene MAPT and Alzheimer disease.