Bcl11a and 11b were first discovered by Satterwhite et al., 2001 when they found a translocation of t(2:14) (p13;q32.1) B cell malignancies causing dysfunction of Bcl11a, an immunoglobulin heavy chain gene, and its close relative Bcl11b (Satterwhite et al., 2001) with deletions or missense mutations present in 9% of mature T-ALL specimens (Kamimura et al., 2007; Gutierrez et al., 2011). The gene discussed is BCL11A; the disease is acute lymphoblastic leukemia.