CLU and neuroblastoma: In an early report, the ability of clusterin to inhibit the toxicity of preformed oligomers of Aβ42 and of the SH3 domain of phosphatidylinositol 3-kinase (PI3-SH3) was observed on human neuroblastoma SH-SY5Y cells at 1:10 clusterin:substrate ratio (Yerbury et al., 2007).