It is remarkable that this level of overexpression of GRP78, reported in vivo in this animal model and similar to those observed in post-mortem human AD tissue, is minor compared to the levels induced by ER stress (e.g., by using tunicamycin) in a wild-type animal, which can be more than 3-fold in several tissue types (Li et al., 2012; Galán et al., 2014). Here, HSPA5 is linked to Alzheimer disease.