Some authors have found that another ER-resident protein dnj-27 (the ortholog of mammalian ERdj5), which works as an enhancer of ERAD together with GRP78 and EDEM, protects against the aggregation of both Aβ and α-synuclein (α-syn), involved in PD pathogenesis, in C. elegans (Muñoz-Lobato et al., 2014). This evidence concerns the gene HSPA5 and Parkinson disease.