Autoantibodies from serum of prostate cancer patients against a segment of GRP78 (Leu 98-Leu115) induces cell proliferation, suggesting that these antibodies serve as agonists of activated α2-M, which recognizes the same site of GRP78 (Gonzalez-Gronow et al., 2006). The gene discussed is HSPA5; the disease is Familial prostate cancer.