CRB1 and Leber congenital amaurosis: These models mimic the diverse phenotypes and severities observed in patients with CRB1-linked retinal dystrophies, including LCA, early-onset RP, telangiectasia, and mild retinopathies (van de Pavert et al., 2004; Alves et al., 2013b; Pellissier et al., 2013, 2014b; Zhao et al., 2015).