Increased DNA damage response through hyperactivation of PARP-1 [poly (ADP-ribose) polymerase-1] can inhibit mitophagy by disrupting the NAD+-sirtuin-PGC-1α axis in cells developed from xeroderma pigmentosum group A patients (Fang et al., 2014b). Here, PARP1 is linked to xeroderma pigmentosum.