A concomitant increase (p < 0.01) in the median fluorescence intensity (MFI) of CD3+CD8+TLR4+ T cells was observed in RA patients (840.8 ± 196.1) in comparison to the healthy donors (174.2 ± 39.8) (Fig. 1c). This evidence concerns the gene TLR4 and rheumatoid arthritis.