TLR4 and rheumatoid arthritis: The ROC curve generated to determine the sensitivity and the specificity of the TLR4 expression on CD8+ T cells of RA patients in comparison to the healthy controls further demonstrates that TLR4 levels on CD8+ T cells are accurately distinguishing patients with RA from the healthy individuals (Area = 0.77, p < 0.01) (Fig. 2d).