Moreover, all these CD8+ T cell subsets co-expressed Granzyme B. The significant differences in Granzyme B expression were observed in effector (38.73 ± 11.2% cells) lymphocytes of RA patients (Fig. 3c) while expression level for Granzyme B in the healthy controls remained very low (3.125 ± 2.63% cells). This evidence concerns the gene CD8A and rheumatoid arthritis.