PRF1 and rheumatoid arthritis: A robust increase in mRNA transcripts and increased average fold changes of mRNA transcripts of Granzyme B (479.4 ± 159.7 fold), Perforin (296.5 ± 96.9 fold), TNFα (68.3 ± 17.7 fold), and IFNγ (175.4 ± 40.26 fold) was observed in RA patients as compared to healthy controls (Fig. 3a).