VEGFA and cancer: In particular, Salazar-Ramiro et al. [21] sustained that inflammation increases cancer risk leading to development and progression of cancerous cells, besides, inflammatory cells are frequently in tumors that expressed cytokines, growth factors, prostaglandins, reactive oxygen species (ROS), extracellular matrix-degrading enzymes and angiogenic factors (vascular endothelial growth factor -VEGF), and MMP9.