LDHA and melanoma: The heterogeneous nature of melanomas make an intriguing model to study metastatic dissemination as they have been reported, among many classes of solid tumors, to harbor cancer initiating cell (CIC) populations identified by several biomarkers including aldehyde dehydrogenase (ALDH) [23, 24], CD20 [21], CD133 [25], CD271 [26], and ABCB5 [22].