Considering that Granta-519 and JVM-2 cells were more friendly to lentivirus and these two cell lines can be especially recommended for in vivo study of p53-mutated and p53-wild chronic lymphocytic leukemia and in which TRIP13 expression level are similar, these 2 cell lines were employed in the further study [17, 18]. The gene discussed is TP53; the disease is B-cell chronic lymphocytic leukemia.