Besides, three genes (NME1, TERC and POT1) associated with ER status, NME1 and RTEL associated with HER2 status, ATRX and NBS1 associated with the lymph node metastasis, ATRX associated with TP53 mutation status, TNKS1 associated with the PR status were found in our cohort. The gene discussed is NME1; the disease is metastatic malignant neoplasm in the lymph nodes.