PTEN and glioblastoma: Briefly, we found that (a) the two GBM lines exhibited very different migratory patterns, i.e. directionally persistent vs. random movement; (b) inhibition of PI3K/mTOR greatly reduced migration of the less invasive DK-MG cells (PTEN wt, p53 wt), without affecting migration of the highly invasive SNB19 cells (PTEN mut, p53 mut); (c) in contrast, the Hsp90 inhibitor AUY922 exerted in both cell lines strong anti-migratory effects, which were further enhanced by the addition of PI-103 (Figures 1 and 2).