Sub-group analyses (Table 3) showed that the expression level of HDAC1 in the low-differentiated cancer patients was higher than that in the moderate/high-differentiated cancer patients with colorectal cancer (OR = 3.80, 95% CI = 1.46–9.92) and liver cancer (OR = 2.50, 95% CI = 1.45–4.30). Here, HDAC1 is linked to cancer.