Although there was no correlation between HDAC1 expression and OS of colorectal cancer, liver cancer and pancreatic cancer patients, we found that gastric cancer patients with low HDAC1 expression showed better OS than those with high HDAC1 expression, indicating that HDAC1 might be a good prognostic marker for gastric cancer patients and could help screen out high-risk patients with gastric cancer. Here, HDAC1 is linked to familial pancreatic carcinoma.