Even more importantly, the supernatants collected from Btk inhibitors-treated macrophages also strongly diminished the motility of T-cell lymphoma Hut78 cells, suggesting immunomodulatory effects of Btk inhibition on macrophages presented in the tumor microenvironment may also have therapeutic value in lymphatic malignancies not driven by Btk expression (Figure 3B and 3C; Supplementary Figure 2). Here, BTK is linked to neoplasm.