ITGB6 and graft versus host disease: Consistent with these results, blockade of IFN-I signaling 2 days before TBI-induced damage abrogated the 3pRNA-induced increase in barrier function (Fig. 4C) and the increase in RegIIIγ and Itgb6 expression during GVHD (Fig. 4, D and E), and reversed the inhibition of neutrophil influx into the gut mucosa after TBI-induced intestinal damage in WT mice (Fig. 4F).