The role of IL-6 was evaluated using IL-6 overexpression [14, 26], recombinant IL-6 administration [15, 16, 28, 32], IL-6-blocking antibodies [28, 32] and IL-6 deficiency [15, 16, 29–32]. This evidence concerns the gene IL6 and hyperinsulinemic hypoglycemia, familial, 4.