IL6 and bacterial pneumonia: The role of IL-6 in ARDS has been actively investigated over the past decades in various rodent models, including hyperoxia [14, 26], inhalation or aspiration of bacterial particles [15, 27], IgG aspiration [28], acid aspiration [29, 30], bacterial pneumonia [16], LPS intratracheal instillation [31] or aerosol inhalation [15] and high tidal volume-associated lung injury [30, 32].