IL4 and obesity due to melanocortin 4 receptor deficiency: Interestingly, a non-significant association, previously observed between V and lower methylation of IL4 CpG−326 among overweight asthmatic children, became significant when overweight was replaced by obesity (RR [95% CI]: 0.40 [0.24-0.68]; p = 0.001), high-BF (RR [95% CI]: 0.47 [0.27- 0.80]; p = 0.006), or high-WC in asthmatic children (RR [95% CI]: 0.21 [0.08- 0.53]; p = 0.001).