Meng Zhou etc. identified a 17-lncRNA signature to classify subtype and predict prognosis in 1,118 patients with DLBCL [38]; Yuling Yan etc. reported a lncRNA HOTAIR could predict a poor prognosis, which promotes cell proliferation and is correlated with tumor size and IPI [39]; Wei Peng etc. demonstrated that the lncRNA LUNAR1 and PEG10 as indicators of poor survival rate may play a key oncogene role promoting cell proliferation for DLBCL patients [40, 41]. The gene discussed is HOTAIR; the disease is diffuse large B-cell lymphoma.