In particular, sub-analysis revealed that high mRNA expression of TRPS1 was significantly associated with better survival in ER positive (HR=0.64, p=7e-06), but not in ER negative BC (HR=0.76, p=0.41) (Figure 7B and 7C), furthermore, the results also demonstrated that TRPS1 high expression was significantly associated with longer RFS in luminal A (HR=0.67, p=0.0016), luminal B (HR=0.71, p=0.031), and Her-2 positive (HR=0.54, p=0.027), but not in Her-2 subtype (HR=1.13, p=0.61), Her-2 negative (HR=0.76, p=0.66) or basal-like subtypes BC (HR=0.81, p=0.2) (Figure 7D-7I). Here, ESR1 is linked to breast cancer.