ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: Moreover, with our observation that BCR-ABL expression leads to a strong decrease of B220+ B cells in the bone marrow and the spleen [19], and with the evidence by Oksvold and colleagues shown that dasatinib induces apoptosis in normal B cells [2], we studied how dasatinib affects B- and T cells as well as NK cells in a CML in vivo model (both in a steady-state setting or after transplantation of BCR-ABL positive bone marrow stem cells).