Consistent with this finding, RSU-1 was demonstrated to be significantly upregulated in the aggressive MDA-MB-231 breast cancer cells compared to less aggressive MCF-7 cells [18], as well as in the aggressive HepG2 hepatocellular carcinoma cells compared to the less invasive PLC/PRF/5 (Alexander) hepatoma cells [19]. The gene discussed is HSPG2; the disease is hepatocellular carcinoma.