A study in familial adenomatous polyposis involving a small number of samples showed a reduction in RSU-1 protein expression in polyposis samples compared to normal colonic mucosa [15] while another study showed RSU-1 mRNA expression to be dramatically up-regulated in metastatic colon cancer samples compared to healthy controls as well as compared to primary colon cancer samples [16]. The gene discussed is RSU1; the disease is colonic neoplasm.