CREB1 and cancer: Furthermore, increased UCA1 promotes cancer invasion and metastasis by activation of metastasis genes including MMP14, FGFR1/ERK and ZEB1/2-FSCN1, and enhances chemoresistance by a set of anti-apoptosis genes and signaling pathways (PARP/BCL-2, CREB1/BCL-2/RAB22A, AKT/mTOR and Wnt signaling pathway) [11, 13, 19, 21, 24, 31–33].