TP53 and breast cancer: To further investigate the effect of NDRG2 in ADR resistance of breast cancer cells, we overexpressed NDRG2 in breast cancer cells with different p53 status, two mutant p53 cell lines: T47D (L194F) and MDA-MB-231(R280K), and one wildtype p53 cell line MCF-7 (Figure 2A).