Warth et al. [48] investigated 189 primary gliomas of WHO grade I-IV along with 31 recurring glioblastoma tumors to obtain a more in-depth understanding regarding the role of AQP4 in human brain tumor edema and, more importantly, to explore whether a direct association between AQP4 expression levels and mortality could be found. Here, AQP4 is linked to central nervous system cancer.