RIPK3 and infection: A whole-genome screen for mediators of RIP3-mediated necroptosis identified several regulators of antiviral and antimicrobial innate immunity [14], and numerous studies have shown that RIP3 and the related kinase RIPK1 control necrotic and inflammatory outcome after infection by certain bacteria and viruses, as well as after exposure of cells to select pathogen-associated molecular patterns (PAMPs) and cytokines [15–17].