To date, investigators have largely inferred that necroptosis exacerbates tissue injury because the inhibition of RIP3 has been shown to be beneficial in many tissue injury models, including pancreatitis [23, 24] atherosclerosis [25], retinal degeneration [26], kidney ischemia-reperfusion injury [27], Gaucher's disease [28], myocardial infarction[29, 30], and systemic inflammatory response (SIRS) syndrome [31]. This evidence concerns the gene RIPK3 and atherosclerosis.