By suppressing the expression of epithelial markers such as E-cadherin, increasing the expression of mesenchymal markers including N-cadherin, Vimentin, Slug, Snail, Fibronectin, ZEB1, and enhancing the nuclear translocation of β-catenin, the cells acquire the ability to migrate and invade, which could lead to tumor progression and metastasis [25]. This evidence concerns the gene CDH2 and neoplasm.