TALNEC2 (also termed ENST00000295549 [Ensembl] and LINC01116 [RefSeq]) was originally identified as a putative E2F1-regulated lncRNA [10] through a deep-sequencing analysis preformed using U2OS human osteosarcoma cells and H1299 human non-small-cell lung carcinoma cells expressing a conditionally overexpressed E2F1 vector (Figure 1A). The gene discussed is E2F1; the disease is osteosarcoma.