Because VSMCs rather than vascular endothelial cells are involved in arteriosclerosis associated with HGPS, we tested the influence of progerin on the growth of VSMCs and human umbilical vein endothelial cells (HUVECs) by using a retroviral vector that encoded wild-type lamin A or progerin. This evidence concerns the gene LMNA and Hutchinson-Gilford progeria syndrome.