According to interactome analysis, progerin showed the largest loss and smallest gain in the number of protein-protein interactions compared with wild-type lamin A. These results led us to hypothesize that the normal lamin A protein network is most severely disrupted in HGPS among the laminopathies associated with premature aging and that alterations of protein interactions may contribute to the characteristic phenotypic features of this disease. This evidence concerns the gene LMNA and laminopathy.