Ataxia telangiectasia mutated (ATM) is a kinase that is rapidly and specifically activated in response to DNA double-strand breaks, and it was found to be activated in Zmpste24−/− mice as well as in Lmna G609G/G609G mice that produce progerin and display clinical features of HGPS [8]. This evidence concerns the gene LMNA and Hutchinson-Gilford progeria syndrome.