HOXB4 and acute myeloid leukemia: HOX gene expression at the RNA level has also been shown to have prognostic significance in acute myeloid leukaemia (AML) [41], and in several solid malignancies including mesothelioma (HOXB4) [42], breast cancer (HOXB7) [43], ovarian cancer [44], oral squamous cell carcinoma (HOXD13) [45], thyroid cancer (HOXC10) [46], clear cell renal cell carcinoma (HOXC11) [47], gastric cancer (HOXC6) [48], and bladder cancer (HOXB13) [49].