RHO and non-small cell lung carcinoma: Our results demonstrate that micro-molar concentrations of PCAIs diminish Rho protein levels and an F-actin-binding protein from the plasma membrane in a time-dependent manner; disrupt filopodia and lamellipodia formation in a time-dependent manner; disrupt F-actin assembly, promote cell rounding, and inhibit 2D and 3D NSCLC migration and invasion.