POLE and colorectal carcinoma: In this sense, when comparing with POLE-exonuclease mutant CRC tumor samples present in the COSMIC database (e.g. TCGA-CA-6718-01, P286R, 5,946 substitutions; and TCGA-A6-6141-01, p.S297F, 1,981 substitutions), a hypermutated profile was not evident.