PTEN and esophageal squamous cell carcinoma: It is worthy to note that in another 2 case-control studies, one observed that the distribution of genotypes or alleles at PTEN rs701848 T/C possessing notably higher proportion in ESCC cases (n=304) than in the controls (n=413) [6], however, the other study did not found any significant differences of the genotype in PTEN rs701848 in ESCC patients (n=226) [18].