One study investigated PTEN rs701848, PIK3CA rs2699887 polymorphisms in a case-control study that consisted of 780 colorectal cancer patients and 764 cancer-free controls, and observed that PTEN rs701848 variants were associated with colorectal cancer risk and prognosis of CRC patients treated with FOLFOX regimen [12]. This evidence concerns the gene PTEN and colorectal cancer.