PIK3CA and neoplasm: To further evaluate the existence of possible gene, clinical parameters interaction in association with the clinical outcomes, high-order interactions assessed by using the MDR analysis was performed with inclusion of the 3 selected SNPs (i.e., PTEN rs701848, PIK3CA rs2699887, and AKT1 rs2494752) and 7 known risk factors (i.e., age at diagnosis, menopausal status, family history, tumor size, clinical stages, lymph node metastasis, histology.