AKT1 and breast cancer: Multivariate Cox regression model analysis also evaluated AKT1 rs2494752 GG genotype as the independent prognostic factor for BC (DFS: adjusted HR=1.523, 95% CI=1.012-2.293, P=0.044; OS: adjusted HR=2.321, 95% CI=1.281-4.204, P=0.005)(Table 3).