PTEN and breast cancer: To further confirm the predictive effect of the SNPs on prognosis, multivariate Cox regression analysis and Kaplan-Meier analysis were performed to evaluate the correlations between genetic polymorphisms of PTEN rs701848, PIK3CA rs2699887, and AKT1 rs2494752 and the prognosis of BC patients after treated with CE(A)F regimen chemotherapy (n=594).