The single nucleotide polymorphisms (SNPs) in many candidate genes, especially in signal transduction pathways including the phosphatase and tensin homolog deleted on chromosome10 (pTEN)/phosphatidylinositol-4,5- bisphosphate 3-kinase catalytic subunit alpha (PI3K)/AKT serine/threonine kinase 1(AKT) signaling pathway, often contribute to the origin, propagation, and treatment responses of a cancer and prognosis [5–8]. Here, PIK3CA is linked to cancer.