In light of the critical role of the PTEN/PI3K/AKT pathway in maintaining proper cellular function, it is possible that some candidate functional SNPs of genes which located in the 5′-untranslated regions (5′UTR) and 3′ UTRs of this pathway may have an effect on susceptibility and response to chemotherapy and prognosis of breast cancer. Here, AKT1 is linked to breast carcinoma.