CASP3 and prostate carcinoma: Here, we showed that BITC effectively reduced cell viability in both hormone-sensitive (CWR22Rv1, Rv1) and hormone-refractory (PC3) human prostate cancer cell lines by disrupting the mitochondrial membrane potential (MMP), inducing caspase 3/7 activity and increasing DNA fragmentation, which are characteristics of apoptosis induction.