Moreover, the secretion of several chemokines by CAFs (including CXCL12/SDF1 and CCL2/MCP-1) can potentially attract macrophages in the tumor microenvironment and induce their differentiation into an M2 immunosuppressive phenotype [30, 31], and also allow the recruitment of immunosuppressive MDSC populations in the stroma [32, 33]. Here, CXCL12 is linked to neoplasm.