Moreover, RT-qPCR experiments showed that CAF1-4 mostly expressed MMP1,2,3 and 9 at the mRNA level (data not shown), narrowing the list of MMPs possibly involved in the CAF CMs-dependent shedding of MICA/B at the surface of melanoma tumor cells to MMP1,2,3 and 9. The gene discussed is MMP1; the disease is melanoma.