Together, these results correlate with the restoration of MICA/B expression at the surface of CAFs CMs-treated T1 tumor cells following GM6001 treatment and demonstrate that MMPs present in the CAFs CMs are, at least partially, responsible for the decreased susceptibility of melanoma tumor cell susceptibility to NK cell-mediated lysis though a diminished NKG2D-dependent NK cell activation. Here, KLRK1 is linked to neoplasm.